Association pour la Recherche en Physiologie de l'Environnement

Publications

Articles

  • Morel O-E, Buvry A, Le Corvoisier P, Tual L, Favret F, Léon-Velarde F, Crozatier B, Richalet J-P. Effects of nifedipine-induced pulmonary vasodilatation on cardiac receptors and protein kinase C isoforms in the chronically hypoxic rat. Pflugers Arch. Eur. J. Physiol. 446 : 356-364, 2003
  • Richalet J-P. Facteurs limitants de la performance en haute altitude : opération Everest III, Comex’97. Science et Sports 18 : 11-15, 2003.
  • Bouassida A, Zaouali M, Latiri I, Zelleg D, Ben Mdella S, Richalet J-P, Tabka Z. Cinétique du cortisol et de l’hormone de croissance plasmatiques lors de deux épreuves sous-maximales avec et sans récupération. Science et Sports 18 : 20-22, 2003
  • Favret F, Henderson KK, Richalet J-P, Gonzalez NC. Effects of exercise training on acclimatization to hypoxia: systemic O2 transport during maximal exercise. J Appl Physiol. 95:1531-1541, 2003
  • Richalet J-P. Oxygène et physiologie dans les milieux extrêmes: un modèle et ses applications. Ann Biol Clin 61: 203-205, 2003
  • Trabelsi Y, Ben Saad H, Tabka Z, Gharbi N, Bouchez Buvry A, Richalet J-P, Guenard H. Spirometric reference values in Tunisian children. Respiration 71: 511-518, 2004
  • Bouassida A, Zelleg D, Zaouali M, Gharbi N, Fekih Y, Richalet J-P, Tabka Z. Effets d’un exercice supra-maximal sur les concentrations de la leptine plasmatique. Science et Sports 19: 136-138, 2004
  • Cornolo J, Mollard P, Brugniaux JV, Robach P, Richalet J-P. Autonomic control of the cardiovascular system during acclimatization to high altitude: effects of sildenafil. J Appl Physiol 97: 935-940, 2004
  • Robach P, Fulla Y, Westerterp K R, Richalet J-P. Comparative response of EPO and soluble transferrin receptor at high altitude. Med Sci Sports Exerc 36:1493-1498, 2004
  • Woorons X, Mollard P, Lamberto C, Letournel M, Richalet J-P. Effect of acute hypoxia on maximal exercise in trained and sedentary women. Med Sci Sports Exerc 37 : 147-154, 2005
  • Richalet J-P, Gratadour P, Robach P, Pham I, Déchaux M, Joncquiert-Latarjet A, Mollard P, Brugniaux J, Cornolo J. Sildenafil inhibits the altitude-induced hypoxemia and pulmonary hypertension. Am J Respir Crit Care Med 171: 275-281, 2005
  • Tiollier E, Schmitt L, Burnat P, Fouillot J-P, Robach P, Filaire E, Guezennec CY, Richalet J-P. “Living High –Training Low ” altitude training: effects on mucosal immunity. Eur J Appl Physiol 94:298-304. 2005
  • Leon-Velarde F, Maggiorini M, Reeves JT, Aldashev A, Asmus I, Bernardi L, Ge RL,Hackett P, Kobayashi T, Moore LG, Penaloza D, Richalet JP, Roach R, Wu T, Vargas E, Zubieta-Castillo G, Zubieta-Calleja G. Consensus statement on chronic and subacute high altitude diseases. High Alt Med Biol. 6:147-157, 2005.
  • Povea C, Schmitt L, Brugniaux J, Nicolet G, Richalet J-P, Fouillot J-P. Effects of Intermittent Hypoxia on Heart Rate Variability during Rest and Exercise. High Alt Med Biol 6:215-225, 2005
  • Roels B, Schmitt L, Libicz S, Bentley D.J, Richalet J-P and Millet G.P. Specificity of VO2max and the ventilatory threshold in free swimming and cycle ergometry: comparison between triathletes and swimmers. Brit J of Sports Med 39:965-968, 2005
  • Morel OE, Aubert R, Richalet J-P, Chapelot D. Simulated high altitude selectively decreases protein intake and lean mass gain in rats. Physiology & Behavior 86:145-153, 2005
  • Cornolo J, Brugniaux JV, Macarlupu JL, Privat C, León-Velarde F and Richalet J-P. Autonomic adaptations in Andean trained participants to a 4,220m altitude marathon. Med Sci Sports Exerc. 37:2148-2153, 2005
  • Richalet J-P, Rivera M, Bouchet P, Chirinos E, Onnen I, Petitjean O, Bienvenu A, Lasne F, Moutereau S and León-Velarde F. Acetazolamide, a treatment for chronic mountain sickness. Am J Resp Crit Care Med. 172:1427-1433, 2005
  • Gonzalez NC, Henderson KK, Favret F and Richalet JP. Rats living high, training low, show polycythemia-mediated increase in VO2max in spite of reduced tissue O2 extraction. J Appl Physiol. 99:2456, 2005
  • Brugniaux JV, Schmitt L, Robach P, Jeanvoine H, Zimmermann H, Nicolet G, Duvallet A, Fouillot J-P and Richalet J-P. Living High – Training Low: Tolerance and acclimatization in elite endurance athletes. Eur J Appl Physiol. 96: 66-77, 2006
  • Roels B, Hellard P, Schmitt L, Robach P, Richalet J-P and G.P. Millet. Is it more effective to live and train at 1200 m than at 1850 m in term of performance and haematological benefits in highly trained swimmers ? Brit J Sports Med 40(2): e4, 2006
  • Brugniaux JV, Schmitt L, Robach P, Nicolet G, Fouillot JP, Moutereau S, Lasne F, Pialoux V, Saas P, Chorvot MC, Cornolo J, Olsen NV, Richalet JP. Eighteen days of « living high, training low » stimulate erythropoiesis and enhance aerobic performance in elite middle-distance runners. J Appl Physiol. 100: 203-211, 2006
  • Favret F, Henderson KK, Richalet J-P, Gonzalez NC. Exercise training improves lung gas exchange, attenuates acute hypoxic pulmonary hypertension, but does not prevent pulmonary hypertension of prolonged hypoxia. J Appl Physiol. 100: 20-25, 2006
  • Macarlupu JL, Buvry A, Morel O-E, Leon-Velarde F, Richalet J-P, Favret F. Characterisation of ventilatory response to hypoxia in a model of transgenic anemic mice. Respir Physiol Neurobiol. 150 : 19-26, 2006a
  • Macarlupú JL, Buvry A, Morel O-E, Leon-Velarde F, Richalet J-P, Favret F. Time course of ventilatory acclimatization to hypoxia in a model of anemic transgenic mice. Respir Physiol Neurobiol , 153: 14-22, 2006b
  • Schmitt L, Hellard P, Millet GP, Roels B, Richalet J-P, Fouillot J-P. Heart rate variability and performance at two different altitudes in well-trained swimmers. Int J Sports Med 27: 226-231, 2006
  • Cornolo J, Fouillot J-P, Schmitt L, Povea C, Robach P, and Richalet J-P. Interactions between exposure to hypoxia and the training-induced autonomic adaptations in a « live high-train low » session. Eur J Appl Physiol. 96 : 389-396, 2006
  • Robach P, Schmitt L, Brugniaux J, Roels B, Millet G, Hellard P, Nicolet G, Duvallet A, Fouillot J-P, Moutereau S, Lasne F, Pialoux V, Olsen NV and Richalet J-P. Living high – training low: Effect on erythropoiesis and aerobic performance in highly trained swimmers. Eur J Appl Physiol 96: 423-433, 2006
  • Tual L, Morel O-E, Favret F, Guernier C, Buvry A, Germain L, Bernaudin J-F, Richalet J-P. Carvedilol inhibits right ventricular hypertrophy induced by chronic hypobaric hypoxia. Pfugers Arch 452 :371-379, 2006
  • León-Velarde F, Richalet J-P. Respiratory Control in Residents at High Altitude: Physiology and Pathophysiology. High Alt Med Biol 7 :125-137, 2006
  • Mounier R, Fellmann N, Pialoux V, Cayre A, Schmitt L, Richalet J-P, Robach P, Lasne F, Roels B, Millet G, Coudert J, Clottes E. Leukocyte’s HIF-1 expression and training-induced erythropoietic response in swimmers. Med Sci Sports Exerc 38:1410-1417, 2006
  • Robach P, Schmitt L, Brugniaux JV, Nicolet G, Duvallet A, Fouillot J-P, Pialoux V, Moutereau S, Lasne F, Olsen NV and Richalet J-P. Living high – training low: effect on erythropoiesis and maximal aerobic performance in elite Nordic skiers. Eur J Appl Physiol 97:627-636, 2006
  • Schmitt L, Millet G, Robach P, Nicolet G, Brugniaux J, Fouillot J-P, Richalet J-P. Influence of « Live high – train low » on performance and economy of work in elite endurance athletes. Eur J Appl Physiol 97: 627-636, 2006
  • Pialoux V, Mounier R, Ponsot E, Rock E, Mazur A, Dufour S, Richard R,Richalet JP, Coudert J, Fellmann N. Effects of exercise and training in hypoxia on antioxidant/pro-oxidant balance. Eur J Clin Nutr. 60:1345-54, 2006.
  • Woorons X, Mollard P, Pichon A, Lamberto C, Letournel M, Richalet J-P. Submaximal exercise in hypoxia induces a greater arterial desaturation in trained than untrained men. Scandinavian Journal of Medicine and Science in Sports 17: 431-436, 2007.
  • Mollard P, Woorons X, Letournel M, Cornolo J, Lamberto C, Beaudry M, Richalet JP. Role of maximal heart rate and arterial O2 saturation on the decrement of VO2max in moderate acute hypoxia in trained and untrained men. Int J Sports Med.28:186-192, 2007
  • Richalet J-P. A proposed classification of environmental adaptation : the example of high altitude. Reviews Env Science Biotech 6:223-229, 2007
  • Trabelsi Y, Z. Tabka Z, Richalet J-P, Gharbi N, Bienvenu A, Guenard H, Buvry A. Spirometric Values in Tunisian children: relationship with pubertal status. Ann Human Biol 34 :195-205, 2007
  • Woorons X, Mollard P, Pichon A, Duvallet A, Richalet J-P, Lamberto C. Prolonged expiration down to residual volume leads to severe arterial hypoxemia in athletes during submaximal exercise. Respir Physiol Neurobiol 158 :75-82, 2007
  • Mollard P, Woorons X, Letournel M, Lamberto C, Favret F, Pichon A, Beaudry M, Richalet J-P. Determinants of maximal oxygen uptake in moderate acute hypoxia in endurance athletes. Respir Physiol Neurobiol, 100:663-673, 2007.
  • Favret F, Richalet J-P. Exercise in hypoxia: the role of the autonomous nervous system. Respir Physiol Neurobiol 158:280-286, 2007.
  • Mollard P, Woorons X, Letournel M, Lamberto C, Favret F , Pichon A, Beaudry M and Richalet J-P. Determinant factor of aerobic performance in moderate acute hypoxia in women endurance athletes. Respir Physiol Neurobiol 159:178-186, 2007.
  • Schmitt L, Fouillot JP, Millet GP, Robach P, Nicolet G, Brugniaux J, Richalet JP. Altitude, Heart rate variability and aerobic capacities.Int J Sports Med. 29:300-306, 2008
  • El Hasnaoui-Saadani R, Cardenas Alayza R, Launay T, Pichon A, Quidu P, Beaudry M, Leon-Velarde F, Richalet JP, Duvallet A, Favret F. Brainstem NO modulates ventilatory acclimatization to hypoxia in mice. J Appl Physiol. 103:1506-1512, 2007.
  • Woorons X, Mollard P, Pichon A, Duvallet A, Richalet J-P, Lamberto C. Effects of a 4-week training with voluntary hypoventilation carried out at low pulmonary volumes. Respir Physiol Neurobiol 160: 123-130, 2008.
  • Richalet JP, Chenivesse C, Larmignat P, Meille L. High altitude pulmonary oedema, Down syndrome and obstructive sleep apneas. High Alt Med Biol 9:179-181, 2008.
  • Richalet JP, Rivera M, Maignan M, Privat C, Pham I, Macarlupu JL, Petitjean O, León-Velarde F. Acetazolamide for Monge’s disease: efficiency and tolerance. Am J Respir Crit Care Med 177:1370-1376, 2008
  • Richalet JP, Gore CJ. Live and/or sleep high – train low, using normobaric hypoxia. Scand J Med Sci Sports, 18 (Suppl 1) : 29-37, 2008
  • Rivera-Ch M, Huicho L, Bouchet P, Richalet JP, León-Velarde F. Effect of acetazolamide on ventilatory response in subjects with chronic mountain sickness. Respir Physiol Neurobiol. 162: 184-189, 2008.
  • Brugniaux JV, Niva A, Pulkkinen I, Laukkanen RM, Richalet JP, Pichon AP. Polar Activity Watch 200: a new device to accurately assess energy expenditure. Br J Sports Med. 2008 Apr 15. [Epub ahead of print]
  • Mollard P, Woorons X, Antoine-Jonville S, Jutand L, Richalet JP, Favret F, Pichon A.’Oxygen uptake efficiency slope’ in trained and untrained subjects exposed to hypoxia. Respir Physiol Neurobiol 161:167-173, 2008.
  • Trabelsi Y, Pariès J, Harrabi I, Zbidi A, Tabka Z, Richalet JP, Buvry A. Factors affecting the development of lung function in Tunisian children. Am J Hum Biol 20:716-725, 2008
  • Maignan M, Rivera-Ch M, Privat C, León-Velarde F, Richalet J-P, Pham I. Pulmonary pressure and cardiac function in chronic mountain sickness patients. Chest,135:499-504, 2009
  • El Hasnaoui-Saadani R, Pichon A, Marchant D, Olivier P, Launay T, Quidu P, Beaudry M, Duvallet A, Richalet JP, Favret F. Cerebrovascular adaptation to chronic anemia in a model of Erythropoietin deficient mice exposed to hypoxia. Am J Physiol Regul Integr Comp Physiol 296:R801-811, 2009
  • Pialoux V, Mounier R, Rock E, Mazur A, Schmitt L, Richalet JP, Robach P, Coudert J, Fellmann N. Effects of acute hypoxic exposure on prooxidant/antioxidant balance in elite endurance athletes. Int J Sports Med 30:87-93, 2009.
  • Marcora SM, Kayser B, Amann M, Lundby C, Wagner PD, Nybo L, Grassi B, Perrey S, van Lieshout JJ, Marino FE, Brooks GA, Richalet JP. Commentaries on Viewpoint: Evidence that reduced skeletal muscle recruitment explains the lactate paradox during exercise at high altitude. J Appl Physiol 106:739-744, 2009.
  • Pialoux V, Mounier R, Rock E, Mazur E, Schmitt L, Richalet JP, Robach P, Brugniaux J, Coudert J, Fellmann N. Effects of the « Live High – Train Low » method on pro-oxidant/antioxydant balance on elite athletes. Eur J Clin Nutr 63:756-762, 2009
  • Bourdillon N, Mollard P, Letournel M, Beaudry M, Richalet JP. Non-invasive evaluation of the capillary recruitment in the human muscle during exercise in hypoxia. Respir Physiol Neurobiol 165:237-244, 2009
  • Pialoux V., Mounier R., Brugniaux J., Rock E., Mazur A., Richalet J.P., Robach P., Coudert J., and Fellmann N.Thirteen days of « live high – train low » does not affect prooxidant/antioxidant balance in elite swimmers. Eur J Appl Physiol 106:517-524, 2009.
  • Pialoux V, Brugniaux JV, Fellmann N, Richalet JP, Robach P, Schmitt L, Coudert J, Mounier R. Oxidative stress and HIF-1a modulate hypoxic ventilatory responses after hypoxic training on athletes. Respir Physiol Neurobiol 167:217-220, 2009
  • Richalet JP, Gimenez-Roqueplo AP, Peyrard S, Vénisse A, Marelle L, Burnichon N, Bouzamondo A, Jeunemaitre X, Azizi M, Elghozi JL. A role for succinate deshydrogenase genes in low chemoresponsiveness to hypoxia ? Clin Auton Res 19:335-342, 2009
  • Pichon A, Zhenzhong B, Favret F, Jin G, Shufeng H, Marchant D, Richalet JP, Ge RL. Long-term ventilatory adaptation and ventilatory response to hypoxia in plateau pika (Ochotona curzoniae): role of nNOS and dopamine. Am J Physiol Regul Integr Comp Physiol 297: R978 –R987, 2009
  • Bourdillon N, Mollard P, Letournel M, Beaudry M, Richalet JP. Interaction between hypoxia and training on NIRS signal during exercise: contribution of a mathematical model. Respir Physiol Neurobiol 169:50-61, 2009
  • Mounier R, Pialoux V, Schmitt L, Richalet JP, Robach P, Coudert J, Clottes E, Fellmann N. Effects of acute hypoxia tests on blood markers in high-level endurance athletes. Eur J Appl Physiol.106:713-720, 2009
  • Charlot K, Cornolo J, Brugniaux JV, Richalet JP, Pichon A. Interchangeability between heart rate and photoplethysmography variabilities during sympathetic stimulations. Physiol Meas 30: 1357-1369, 2009
  • Pham I, Wuerzner G, Richalet JP, Peyrard S, Azizi M. Endothelin receptors blockade blunts hypoxia-induced increase in PAP in humans. Eur J Clin Invest 40 : 195-202, 2010
  • Launay T, Hagström L, Marchant D, Lottin-Divoux S, Quidu P, Favret F, Duvallet A, Darribère T, Richalet JP, Beaudry M. Blunting effect of hypoxia on the proliferation and differentiation of human primary and rat L6 myoblasts not counteracted by Epo. Cell prolif 43 : 1-8, 2010
  • Hagström L, Canon F, Agbulut O, Marchant D, Serrurier B, Richalet JP, Beaudry M, Bigard X and Launay T. Skeletal muscle intrinsic functional properties are preserved in a model of erythropoietin deficient mice exposed to hypoxia. Pflügers Archiv 459: 713-723, 2010
  • Pialoux V, Brugniaux JV, Rock E, Mazur A, Schmitt L, Richalet JP, Robach P, Clottes E, Coudert J, Fellmann N, Mounier R. Antioxidant status of elite athletes remains impaired 2 weeks after a simulated altitude training camp. Eur J Nutr. 49(5):285-92, 2010
  • Brugniaux JV, Niva A, Pulkkinen I, Laukkanen RM, Richalet JP, Pichon AP. Polar Activity Watch 200: a new device to accurately assess energy expenditure. Br J Sports Med. 44:245-249, 2010.
  • Hagström L, Agbulut O, El-Hasnaoui-Saadani R, Marchant D, Favret F, Richalet JP, Beaudry M, Launay T. Epo is relevant neither for microvascular formation nor for the new formation and maintenance of mice skeletal muscle fibres in both normoxia and hypoxia. J Biomed Biotechnol. 2010 (Epub 2010 Apr 14)
  • Mollard P, Bourdillon N, Letournel M, Herman H, Gibert S, Pichon A, Woorons X, Richalet JP. Validity of arterialized earlobe blood gases at rest and exercise in normoxia and hypoxia. Respir Physiol Neurobiol. 172:179-83, 2010
  • Woorons X, Bourdillon N, Vandewalle H, Lamberto C, Mollard P, Richalet JP, Pichon A. Exercise with hypoventilation induces lower muscle oxygenation and higher blood lactate concentration: role of hypoxia and hypercapnia. Eur J Appl Physiol. 110:367-77, 2010
  • Richalet JP, Letournel M, Souberbielle JC. Effects of high altitude hypoxia on the hormonal response to hypothalamic factors. Am J Physiol Regul Integr Comp Physiol. 299:R1685-92, 2010
  • Bourguignon M, Yaghi L, Flajollet S, Radanne-Krawice I, Rouas-Freiss N, Lugrin D, Richalet JP, Carosella ED, Moreau P. Increased soluble human leukocyte antigen-G levels in peripheral blood from climbers on Mount Everest. Hum Immunol. 71:1105-1108, 2010.
  • Richalet JP, Letournel M, Salama J. Holmes-Addie syndrome associated with High Altitude Pulmonary Edema and low chemoresponsiveness to hypoxia. Clin Auton Res. 21 :55-56, 2011.
  • Woroons X, Bourdillon N, Lamberto C, Vandewalle H, Richalet JP, Mollard P, Pichon A. Cardiovascular responses during hypoventilation at exercise. Int J Sports Med 32 :438-445, 2011
  • Richalet JP, Larmignat P, Poitrine E, Letournel M, Canouï-Poitrine F. Physiological risk factors of severe high altitude illness: a prospective cohort study. Am J Resp Crit Care Med. 2011 (in press)
  • Pham I, Wuerzner G, Richalet JP, Peyrard S, Azizi M. Bosentan effects in hypoxic pulmonary vasoconstriction : preliminary study in subjects with or without high altitude edema history. Pulm. Circ, 2012 (in press)
  • Lhuissier F, Brumm M, Ramier D, Richalet JP. Ventilatory and cardiac responses to hypoxia at submaximal exercise are independent of altitude and exercise intensity. J. Appl. Physiol. 2012

Revues générales

  • Richalet J.-P. Aptitude cardio-vasculaire à l’altitude. In «Cardiologie du sport», Masson éd., 2000, pp 195-199
  • Dumas J.-L., Richalet J.-P., Lamberto C., Petitjean A. 100 Q.C.M. corrigés d’anatomie et de physiologie. Maloine éd., Paris, 2000
  • Richalet J-P. The Endocrine System. In: « High altitude. An Exporation of Human Adaptation ». Lung Biology in Health and Disease. C. Lenfant Series, Vol 161. T.F. Hornbein and R.B. Schoene eds, Marcel Dekker Inc. New York. p 601-644, 2001
  • Richalet J.-P., Larmignat P. Pathologie liée à la haute altitude. In : « Réanimation Médicale ». Sous la direction de J.-M. Boles et coll., Masson éd. 2001, p 1573-1576
  • Richalet J.-P. Alimentation et environnement – Altitude. In: « Apports nutritionnels conseillés pour la population française », 3ème éd. Tec & Doc, Paris, 2001, p 388-390.
  • Richalet J.-P., Larmignat P. Les pathologies d’altitude. In : « Urgences médico-chirurgicales de l’adulte ». Sous la direction de P. Carli et B. Riou. Arnette éd., Paris, 2003, p 800-805.
  • Richalet J.-P. Mal aigu des montagnes et complications. In : « Anesthésie réanimation chirurgicale ». Sous la direction de K. Samii. Flammarion éd., Paris, 2003, p 1176-1180.
  • Richalet J.-P., Herry J.-P. Médecine de l’alpinisme et des sports de montagne, Masson éd. (3ème édition), 2003
  • Richalet J.-P., Herry J.-P. Médecine de l’alpinisme et des sports de montagne, Masson éd. (4ème édition), 2006
  • Richalet J.-P., Larmignat P. Pathologie liée à la haute altitude. In : « Réanimation Médicale ». Sous la direction de J.-M. Boles et coll., Masson éd. 2007, 2ème éd
  • Richalet J-P. Mal aigu des montagnes et ses complications, prevention, preparation à un séjour en montagne. In “ Médecine du sport pour le praticien”. P. Rochcongar et H Monod, Elsevier Masson ed., Paris 2009, chapitre 14.
  • Richalet JP. Altitude, hypoxia and exercise. In Exercise physiology : from a cellular to an integrative approach. P. Connes, O. Hue and S. Perrey eds. IOS press, 2010
  • Richalet JP. Altitude, exercise and training. In « Encyclopedia of exercise medicine in health and disease » Springer-Verlag, 2010
  • Richalet JP. Hypertension artérielle pulmonaire et altitude. In « Hypertension artérielle pulmonaire » dir. G. Simonneau. Med-line éd. 2010
  • Richalet J-P. The Endocrine System. In: « High altitude. An Exporation of Human Adaptation ». Lung Biology in Health and Disease. E Swenson and P Bärtsch eds, in press, 2012